Stem Cell Image Cytometry: Quantitative Strategies for Cell Sourcing in Musculoskeletal Tissue Engineering

About the Presenter

George Muschler, MD
Orthopedic Surgeon
Cleveland Clinic

Dr. George Muschler is a nationally-recognized Cleveland Clinic orthopedic surgeon who has devoted his career to advancing patient care through basic and clinical research and quality management. As a clinician-scientist, his research laboratory focuses on adult stem cell biology and tissue engineering, with particular interest in improving methods for harvesting and processing of human stem cells and progenitors to enhance tissue regeneration and repair, design, and use of quantitative assays of stem cells. His work also focuses on progenitor cells relevant to tissue health and aging, particularly in modulating stem and progenitor cell growth and remodeling kinetics in settings of disease or injury. Dr. Muschler has authorized over ten patents including Colonyze, a quantitative automated image analysis system for assay of stem cells and progenitors.

Webinar Summary

Cells are the core resource for biological products and biomanufacturing. No new tissue is formed without cells. However, cell populations from different donors and tissues are highly variable with respect to the concentration, prevalence, and the biological potential. Managing this variation is a profound challenge in the design, fabrication, and quality control of cell therapies. This webinar will discuss the basic research and the development of a robotic image-based cell picking technology to determine quantitative factors that may predict cell/colony quality.

CMLE Credit: 1.0